Histone Demethylase
There are two classes of enzymes involved in histone methylation: methyltransferases and demethylases. While methyltransferases are responsible for establishing methylation patterns, demethylases are capable of removing methyl groups not only from histones but other proteins as well. Histone demethylases not only target methylated sites on histone tails but also interact with methylated sites on non-histone proteins, such as p53.
Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders.
JMJD1A (also named KDM3A) is a demethylasethat removes methyl from histone lysine H3K9. It plays important roles in various cellular processes, including spermatogenesis, energy metabolism, regulation of stem cell and gender display.
Jumonji domain-containing 3 (Jmjd3) has been identified as a histone demethylase, which specifically catalyzes the removal of methylation from H3K27me3.
Histone Demethylase Isoform Specific Products
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Histone Demethylase Inhibitors
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Histone Demethylase Antagonist
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Histone Demethylase Activators
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Histone Demethylase Degraders
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Histone Demethylase Controls
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Histone Demethylase Ligands
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Histone Demethylase Related Products (297)
Related Products (297)
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Antibodies (8)
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Histone Demethylase Isoform Comparison
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Tranylcypromine hemisulfate (Standard)
0 ImagesSynonyms: SKF 385 hemisulfate (Standard)Tranylcypromine (hemisulfate) (Standard) is the analytical standard of Tranylcypromine (hemisulfate). This product is intended for research and analytical applications. Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects.
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YUKA1 (Standard)
0 ImagesCat. No.: HY-100764RCAS No.: 708991-09-7YUKA1 (Standard) is the analytical standard of YUKA1 (HY-100764). This product is intended for research and analytical applications. YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers.
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NCGC00244536 (Standard)
0 ImagesSynonyms: KDM4B Inhibitor B3 (Standard)NCGC00244536 (Standard) (KDM4B Inhibitor B3 (Standard)) is the analytical standard of NCGC00244536 (HY-101799). This product is intended for research and analytical applications. NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.
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JQKD82 dihydrochloride
0 ImagesCat. No.: HY-138691BCAS No.: 2863635-05-4Synonyms: JADA82 dihydrochloride; PCK82 dihydrochlorideJQKD82 (JADA82) dihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 dihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma.
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EPZ020809
0 ImagesCat. No.: HY-183928CAS No.: 1503332-97-5EPZ020809 is a competitive KDM4C inhibitor with a Ki of 31 nM.
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LSD1-IN-29
0 ImagesCat. No.: HY-160183CAS No.: 1496573-83-1LSD1-IN-29 (compound 6) is a Lysine specific demethylase 1 (LSD1) inhibitor with the IC50 of 19 nM.
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LSD1-IN-37
0 ImagesCat. No.: HY-159901LSD1-IN-37 (Compound 5g) is a lysine-specific demethylase 1 (LSD1) inhibitor constructed using an efficient synthesis strategy incorporating hexafluoroisopropyl groups. This metal-free method exhibits excellent reaction stability and adaptability. LSD1-IN-37 demonstrated outstanding LSD1 inhibitory activity and holds potential for further research.
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NCD-25
0 ImagesCat. No.: HY-123867CAS No.: 1456972-46-5NCD-25 is a selective inhibitor of LSD1 with an IC50 of 0.48 μM.
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Tripartin
0 ImagesCat. No.: HY-119730CAS No.: 1428962-73-5Tripartin is an inhibitor of histone demethylase. Tripartin inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells.
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2-Phenylcyclopropanamine
0 Images2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1. 2-Phenylcyclopropanamine shows no activity against LOXL2.
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Bomedemstat ditosylate (Standard)
0 ImagesCat. No.: HY-109169ARCAS No.: 1990504-72-7Synonyms: IMG-7289 ditosylate (Standard)Bomedemstat ditosylate (Standard) is the analytical standard of Bomedemstat (ditosylate) (HY-109169A). This product is intended for research and analytical applications. Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.
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AS8351 (Standard)
0 ImagesCat. No.: HY-100744RCAS No.: 796-42-9Synonyms: NSC51355 (Standard)
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Corin (Standard)
0 ImagesCat. No.: HY-111048RCAS No.: 1808113-09-8Corin (Standard) is the analytical standard of Corin (HY-111048). This product is intended for research and analytical applications. Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
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Iadademstat (Standard)
0 ImagesCat. No.: HY-109117RCAS No.: 1431304-21-0Synonyms: ORY-1001 (Standard)Iadademstat (Standard) is the analytical standard of Iadademstat (HY-109117). This product is intended for research and analytical applications. Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KdM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research.
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rel-OG-L002 hydrochloride
0 ImagesCat. No.: HY-129127CAS No.: 1357298-75-9rel-OG-L002 hydrochloride (compound OG-L002) is a selective arylcyclopropylamine-based LSD1 inhibitor.
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CPI-455 (Standard)
0 ImagesCat. No.: HY-100421RCAS No.: 1628208-23-0CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
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GSK-J4 hydrochloride (Standard)
0 ImagesGSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1.
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Seclidemstat mesylate (Standard)
0 ImagesCat. No.: HY-103713ARCAS No.: 2044953-70-8Synonyms: SP-2577 mesylate (Standard)Seclidemstat mesylate (Standard) is the analytical standard of Seclidemstat mesylate (HY-103713A). This product is intended for research and analytical applications. Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma.
